N-Methylaniline

  • N-Methylbenzenamine
  • Monomethyl aniline
  • Methylphenylamine
FormulaC6H5NHCH3
Structure
DescriptionColorless to light viscous liquid with a characteristic odor. Turns brown on exposure to air.
UsesOrganic synthesis, solvent, acid acceptor.

Registry Numbers and Inventories.
CAS100-61-8
EC (EINECS/ELINCS)202-870-9
EC Index Number612-015-00-5
EC ClassToxic; Danger of cumulative effects; Dangerous for the Environment
EC Risk PhraseR 23/24/25 33 50/53
EC Safety PhraseS 28 36/37 45 60 61
RTECSBY4550000
RTECS class Other
UN (DOT)2294
Merck12,6098
Beilstein/Gmelin741982
Beilstein Reference4-12-00-00241
Canada DSL/NDSLDSL
US TSCAListed
Austrailia AICSListed
New ZealandListed
Japan ENCS (MITI) Listed
Korea ECLListed

Properties.
Formula C7H9N
Formula mass 107.16
Melting point, C -57
Boiling point, C 196.3
Vapor pressure, mmHg 0.5 (20 C)
Vapor density (air=1) 3.70
Saturation Concentration 395 ppm (0.04%) at 20 C (calculated)
Critical temperature 428
Critical pressure 51.3
Density 0.989 g/cm3 (20 C)
Solubility in water Slightly soluble
Viscosity 2.568 cp @ 15C
Surface tension 39.97 g/s2 @ 15 C
Refractive index 1.5702 (20 C)
pKa/pKb 9.15 (pKb)
Partition coefficient, pKow 1.66
Heat of vaporization 42.2 kJ/mol
Heat of combustion -3314 kJ/mol

Hazards and Protection.
Storage Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store under an inert atmosphere.
WHMIS B3 D1B D2A
Handling Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation. Do not get water inside containers.
Disposal code 9
Stability Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to air.
Incompatibilities Strong oxidizing agents, acids, acid chlorides, acid anhydrides.
Decomposition Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,C79
Autoignition, C500
Upper exp. limit, %7.4
Lower exp. limit, %1.2
Fire fightingWear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Extinguishing media: Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Fire potentialCombustible material: may burn but does not ignite readily.
HazardsWhen heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion productsToxic vapors are generated when heated.
NFPAHealth1
 Flammability2 
 Reactivity0 

Health.
Exposure limit(s)NIOSH REL: TWA 0.5 ppm (2 mg/m3) [skin] OSHA PEL: TWA 2 ppm (9 mg/m3) [skin] IDLH 100 ppm
Exposure effects May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. Prolonged or repeated exposure may cause nausea, dizziness, and headache. Effects may be delayed.
   IngestionMay cause gastrointestinal irritation with nausea, vomiting and diarrhea. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. Effects may be delayed.
   InhalationEffects may be delayed. May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death.
   SkinMay cause skin irritation.
   Eyes May cause eye irritation.

First aid
 
   IngestionIf victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   InhalationRemove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   EyesFlush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number2294
Response guide153
Hazard class 6.1
Packing GroupIII  
USCG CHRIS CodeMAN  
USCG Compatatibility Group 9 Aromatic amines
HS Code 2921 42 90 
Std. Transport # 4925137