Guthion
- Azinphos-methyl
- Phosphorodithioic acid O,O-dimethyl S-((4-oxo-11,2,3-benzotriazin-3-(4H)-yl)methyl) ester
- S-3,4-dihydro-4-oxo-1,2,3-Benzotriazin-3-ylmethyl) O,O-dimethyl phosphorodithioate
Guthion | |
| |
| Formula | C10H12N3O3PS2 |
| Structure | |
| Description | It is a wettable powder. |
| Uses | Nonsystemic insecticide and acaricide. |
| Registry Numbers and Inventories. | |
| CAS | 86-50-0 |
| EC (EINECS/ELINCS) | 201-676-1 |
| EC Index Number | 015-039-00-9 |
| EC Class | Very toxic; Toxic; Sensitising; Dangerous for the Environment |
| RTECS | TE1925000 |
| RTECS class | Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector |
| UN (DOT) | 2783 |
| Merck | 12,944 |
| Beilstein/Gmelin | 280476 |
| Beilstein Reference | 4-26-00-00460 |
| EPA OPP | 58001 |
| Swiss Giftliste 1 | G-1200 |
| Austrailia AICS | Listed |
| New Zealand | Listed |
| Korea ECL | Listed |
| Properties. | |
| Formula | C10H12N3O3PS2 |
| Formula mass | 317.33 |
| Melting point, °C | 73 |
| Boiling point, °C | 401 |
| Vapor pressure, mmHg | 1.2E-6 (25 C) |
| Density | 1.44 g/cm3 (20 C) |
| Solubility in water | Insoluble |
| Refractive index | 1.6115 (20 C) |
| Partition coefficient, pKow | 2.75 |
| Heat of vaporization | 65.1 kJ/mol |
| Heat of combustion | -6277 kJ/mol |
| Hazards and Protection. | |
| Storage | Keep in well ventilated area. |
| Handling | All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. |
| Protection | Wear appropriate chemical protective clothing. |
| Respirators | Wear positive pressure self-contained breathing apparatus. |
| Small spills/leaks | Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Water spill: If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. |
| Stability | Stable. |
| Incompatibilities | Contact with strong oxidizers may cause fires and explosions. Incompatible with alkaline materials. Avoid contact with strong oxidizers, acids. |
| Decomposition | Decomposes at elevated temperatures. When heated to decomposition it emits very toxic fumes of phosphoxides, sulfoxides and oxides of nitrogen. |
| Fire. | ||||
| Flash Point,°C | 196 | |||
| Fire fighting | Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources. | |||
| Fire potential | Nonflammable. | |||
| Hazards | Some of the formulations may burn, but none of them ignite easily. Container may explode in the heat of the fire. Rapidly hydrolyzed by cold alkali or cold acid. Unstable at temperatures above 390F. | |||
| Combustion products | Hazardous decomposition products: Toxic gases and vapors (such as sulfur dioxide, oxides of nitrogen, phosphoric acid mist, and carbon monoxide) may be released from a fire involving azinphos methyl. | |||
| Health. | |
| Exposure limit(s) | TLV: ppm; 0.2 mg/m3 (skin) (ACGIH 1997). MAK: ppm; 0.2 mg/m3; III, H (1996). OSHA PEL: TWA 0.2 mg/m3 skin NIOSH REL: TWA 0.2 mg/m3 skin NIOSH IDLH: 10 mg/m3 |
| Poison_Class | 2 |
| Exposure effects | Fever, low heart rate and abnormally low blood pressure, or rapid heart rate and elevated blood pressure may occur. Headache, dizziness, muscle spasms and profound weakness are common. Alterations of level of consciousness, anxiety, paralysis, seizures and coma may occur. Seizures may be more common in children. |
| Ingestion | Vomiting, hypersalivation, diarrhea, fecal incontinence and abdominal pain may occur. |
| Inhalation | Dyspnea, rales, bronchorrhea, bronchospasm, or tachypnea may be noted. Noncardiogenic pulmonary edema may occur in severe cases. Chemical pneumonitis may be seen. |
| Skin | Sweating is a consistent but not universal sign. |
| Eyes | Constriction of the pupil, tearing, and blurred vision are common. Prolonged dialation of the pupils may occur in severe poisonings. Opsoclonus has been reported in one case. Salivation commonly occurs. |
First aid | |
| Ingestion | The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. |
| Inhalation | Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols. |
| Skin | Remove contaminated clothing and jewelry. Wash the skin, including hair and nails, vigorously; do repeated soap washings. Discard contaminated clothing. |
| Eyes | Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. |
| Transport. | ||
| UN number | 2783 |  |
| Response guide | 152 | |
| Hazard class | 6.1 | |
| Packing Group | I; II; III | |
| USCG CHRIS Code | AZM | |
| Std. Transport # | 4921526 | |