2-Aminopyridine

  • 2-Pyridinamine
  • alpha-Aminopyridine
  • o-Aminopyridine
  • 2-Pyridylamine
Formula 2-(NH2)C5H4N
Structure
Description Colorless crystalline solid, characteristic, unpleasant odor, white leaflets or large colorless crystals, white powder or crystals.
Uses Intermediate in chemical synthesis.

Registry Numbers and Inventories.
CAS 504-29-0
EC (EINECS/ELINCS) 207-988-4
EC Class toxic, irritant
EC Risk Phrase R 21 23/25 33 36/37/38
EC Safety Phrase S 26 36/37/39 45
RTECS US1575000
RTECS class Human Data
UN (DOT) 2671
Merck 13,472
Beilstein/Gmelin 105785
Beilstein Reference 5-22-08-00280
Swiss Giftliste 1 G-1093
Canada DSL/NDSL DSL
US TSCA Listed
Austrailia AICS Listed
New Zealand Listed
Japan ENCS (MITI) Listed
Korea ECL Listed

Properties.
Formula C5H6N2
Formula mass 94.12
Melting point, °C 50 - 52
Boiling point, °C 210.6
Vapor pressure, mmHg 0.2 (25 C)
Vapor density (air=1) 3.25
Saturation Concentration 1053 ppm (0.10%) (calculated)
Density 1.24 g/cm3
Solubility in water Highly soluble
Refractive index 1.56552 (65 C)
pKa/pKb 7.20 (pKb)
Partition coefficient, pKow 0.48
Heat of fusion 15.30 kJ/mol
Heat of vaporization 52.75 kJ/mol
Heat of combustion -2856 kJ/mol

Hazards and Protection.
Storage Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
Handling Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood.
Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Disposal code 3
Stability Stable under normal temperatures and pressures.
Incompatibilities Oxidizing agents, strong acids, acid chlorides, acid anhydrides
Decomposition Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C 93
Autoignition, °C > 630
Fire fighting Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode in the heat of a fire. Combustible solid. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential This chemical is combustible.
Hazards When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products Toxic gases and vapors (such as oxides of nitrogen and carbon monoxide) may be released in a fire involving 2-aminopyridine.
NFPA Health 2
  Flammability 0  
  Reactivity 0  

Health.
Exposure limit(s) TLV: 0.5 ppm; 1.9 mg/m3 (as TWA) (ACGIH 1993-1994). OSHA PEL: TWA 0.5 ppm (2 mg/m3) NIOSH REL: TWA 0.5 ppm (2 mg/m3) NIOSH IDLH: 5 ppm
Poison_Class 2
Exposure effects Weakness, dizziness, disorientation, hyperexcitibility, tremors, periorbital paresthesias and tonic-clonic seizures may be noted.
   Ingestion May be fatal if swallowed. May cause irritation of the digestive tract. Poison by ingestion. May cause effects similar to those for inhalation exposure. An oral dose of 590 mg/kg of 4-aminopyridine in a man produced shortness of breath, nausea, vomiting, hallucinations and distorted perception. Affects the CNS to produce tremor, excitability and convulsions.
   Inhalation Causes respiratory tract irritation. May cause severe headaches, nausea, increased blood pressure, weakness, convulsions, and a stuporous state.
   Skin Causes skin irritation. May be fatal if absorbed through the skin. Substance is rapidly absorbed through the skin. Causes symptoms similar to those of inhalation. Causes redness and pain.
   Eyes Causes eye irritation. Causes redness and pain.

First aid
 
   Ingestion Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number 2671
Response guide 153
Hazard class 6.1
Packing Group II  
USCG Compatatibility Group 7. Aliphatic amines
HS Code 2933 39 99