2-Isopropoxyethanol

  • Ethylene glycol isopropyl ether
  • Isopropyl cellosolve
  • Isopropyl glycol
Formula (CH3)2CHOCH2CH2OH
Structure
Description Colorless liquid with a mild ethereal odor.
Uses Component of lacquers & other coatings, as solvent for resins, dyes for textiles.

Registry Numbers and Inventories.
CAS 109-59-1
EC (EINECS/ELINCS) 203-685-6
EC Index Number 603-013-00-5
EC Class Harmful; Irritant
EC Risk Phrase R 10 20/21 36
EC Safety Phrase S 24/25
RTECS KL5075000
RTECS class Primary Irritant
UN (DOT) 1986
Beilstein/Gmelin 1732184
Beilstein Reference 4-01-00-02380
Swiss Giftliste 1 G-4156
Canada DSL/NDSL DSL
US TSCA Listed
Austrailia AICS Listed
New Zealand Listed
Japan ENCS (MITI) Listed
Korea ECL Listed

Properties.
Formula C5H12O2
Formula mass 104.15
Melting point, °C -60
Boiling point, °C 143
Vapor pressure, mmHg 4 (25 C)
Vapor density (air=1) 3.6
Saturation Concentration 6840 ppm (0.7%) at 25 C (calculated)
Evaporization number 52 (diethyl ether = 1)
Density 0.91 g/cm3 (20 C)
Solubility in water Soluble
Refractive index 1.4095 (20 C)
Dielectric constant 9.9 (20 C)
Partition coefficient, pKow 0.08
Heat of vaporization 43.0 kJ/mol

Hazards and Protection.
Storage See ethers. Ethers should not be stored near powerful oxidizers or in areas of high fire hazard. They should be kept cool and the containers electrically grounded to avoid sparks.
Handling All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection Skin and eye protection should.Be worn if possibility of chemical contact exists. Wear appropriate personal protective clothing and eye protection to prevent contact.
Respirators Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Disposal code 1
Stability Volatile.
Incompatibilities May react violently with strong oxidizing agents.

Fire.
Flash Point,°C 45
Upper exp. limit, % 13.0
Lower exp. limit, % 1.6
Fire fighting Fire Extinguishing Agents: Water, carbon dioxide, dry chemical, alcohol foam.
Fire potential Moderate; can react with oxidizing materials
Combustion products Emits toxic fumes when heated upon decomposition.
NFPA Health 3
  Flammability 2  
  Reactivity 1  

Health.
Exposure limit(s) NIOSH REL: See Appendix D
Poison_Class 5
Exposure effects Coma has been described after ingestion of 30 to 100 ml of pure glycol ethers in adults.
   Ingestion Hemorrhagic gastritis was seen in a case of fatal poisoning with methyl ether.
   Inhalation Ards was reported in one case after ingestion of 500 ml of 9.1% Ethylene glycol butyl ether (egbe).
   Skin Slight irritation.
   Eyes Eye irritation is generally slight, but may be severe with the propyl ether.

First aid
 
   Ingestion Emesis is contraindicated due to rapid gi absorption and potential for rapid progression to coma. Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Correct severe acidosis (ph < 7.1) With iv nahco3. 1 To 2 meq/kg is a useful starting dose. Monitor abgs. Ethanol (etoh) may inhibit the formation of toxic metabolites, but there are no controlled human studies documenting efficacy. Loading dose - administer 7.6 To 10 ml/kg of 10% etoh in d5w iv over 30 minutes. Maintenance dose - administer 1.39 Ml/kg/hr of 10% etoh in d5w by iv infusion. Aim at achieving and maintaining 100 to 130 mg/dl blood ethanol levels.
   Inhalation Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
UN number 1986
Response guide 131
USCG CHRIS Code EGI  
USCG Compatatibility Group 40 Glycol ethers
HS Code 2909 44 00  
IMO Chemical Code 17
IMO Pollution Category D
IMO Hazard code S