2-Isopropoxyethanol
- Ethylene glycol isopropyl ether
- Isopropyl cellosolve
- Isopropyl glycol
2-Isopropoxyethanol | |
| |
| Formula | (CH3)2CHOCH2CH2OH |
| Structure | |
| Description | Colorless liquid with a mild ethereal odor. |
| Uses | Component of lacquers & other coatings, as solvent for resins, dyes for textiles. |
| Registry Numbers and Inventories. | |
| CAS | 109-59-1 |
| EC (EINECS/ELINCS) | 203-685-6 |
| EC Index Number | 603-013-00-5 |
| EC Class | Harmful; Irritant |
| EC Risk Phrase | R 10 20/21 36 |
| EC Safety Phrase | S 24/25 |
| RTECS | KL5075000 |
| RTECS class | Primary Irritant |
| UN (DOT) | 1986 |
| Beilstein/Gmelin | 1732184 |
| Beilstein Reference | 4-01-00-02380 |
| Swiss Giftliste 1 | G-4156 |
| Canada DSL/NDSL | DSL |
| US TSCA | Listed |
| Austrailia AICS | Listed |
| New Zealand | Listed |
| Japan ENCS (MITI) | Listed |
| Korea ECL | Listed |
| Properties. | |
| Formula | C5H12O2 |
| Formula mass | 104.15 |
| Melting point, °C | -60 |
| Boiling point, °C | 143 |
| Vapor pressure, mmHg | 4 (25 C) |
| Vapor density (air=1) | 3.6 |
| Saturation Concentration | 6840 ppm (0.7%) at 25 C (calculated) |
| Evaporization number | 52 (diethyl ether = 1) |
| Density | 0.91 g/cm3 (20 C) |
| Solubility in water | Soluble |
| Refractive index | 1.4095 (20 C) |
| Dielectric constant | 9.9 (20 C) |
| Partition coefficient, pKow | 0.08 |
| Heat of vaporization | 43.0 kJ/mol |
| Hazards and Protection. | |
| Storage | See ethers. Ethers should not be stored near powerful oxidizers or in areas of high fire hazard. They should be kept cool and the containers electrically grounded to avoid sparks. |
| Handling | All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. |
| Protection | Skin and eye protection should.Be worn if possibility of chemical contact exists. Wear appropriate personal protective clothing and eye protection to prevent contact. |
| Respirators | Use NIOSH/MSHA approved respirator appropriate for exposure of concern. |
| Small spills/leaks | Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. |
| Disposal code | 1 |
| Stability | Volatile. |
| Incompatibilities | May react violently with strong oxidizing agents. |
| Fire. | ||||
| Flash Point,°C | 45 | |||
| Upper exp. limit, % | 13.0 | |||
| Lower exp. limit, % | 1.6 | |||
| Fire fighting | Fire Extinguishing Agents: Water, carbon dioxide, dry chemical, alcohol foam. | |||
| Fire potential | Moderate; can react with oxidizing materials | |||
| Combustion products | Emits toxic fumes when heated upon decomposition. | |||
| NFPA | Health | 3 | ||
| Flammability | 2 | |||
| Reactivity | 1 | |||
| Health. | |
| Exposure limit(s) | NIOSH REL: See Appendix D |
| Poison_Class | 5 |
| Exposure effects | Coma has been described after ingestion of 30 to 100 ml of pure glycol ethers in adults. |
| Ingestion | Hemorrhagic gastritis was seen in a case of fatal poisoning with methyl ether. |
| Inhalation | Ards was reported in one case after ingestion of 500 ml of 9.1% Ethylene glycol butyl ether (egbe). |
| Skin | Slight irritation. |
| Eyes | Eye irritation is generally slight, but may be severe with the propyl ether. |
First aid |
|
| Ingestion | Emesis is contraindicated due to rapid gi absorption and potential for rapid progression to coma. Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Correct severe acidosis (ph < 7.1) With iv nahco3. 1 To 2 meq/kg is a useful starting dose. Monitor abgs. Ethanol (etoh) may inhibit the formation of toxic metabolites, but there are no controlled human studies documenting efficacy. Loading dose - administer 7.6 To 10 ml/kg of 10% etoh in d5w iv over 30 minutes. Maintenance dose - administer 1.39 Ml/kg/hr of 10% etoh in d5w by iv infusion. Aim at achieving and maintaining 100 to 130 mg/dl blood ethanol levels. |
| Inhalation | Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols. |
| Skin | Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists. |
| Eyes | Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. |
| Transport. | ||
| UN number | 1986 | |
| Response guide | 131 | |
| USCG CHRIS Code | EGI | |
| USCG Compatatibility Group | 40 Glycol ethers | |
| HS Code | 2909 44 00 | |
| IMO Chemical Code | 17 | |
| IMO Pollution Category | D | |
| IMO Hazard code | S | |