4-Nitroaniline

  • p-Aminonitrobenzene
  • p-Nitroaniline
  • 1-Amino-4-nitrobenzene
Formula H2NC6H4NO2
Structure
Description Yellow solid, ammonia-like odor.
Uses Medication (vet).

Registry Numbers and Inventories.
CAS 100-01-6
EC (EINECS/ELINCS) 202-810-1
EC Index Number 612-012-00-9
EC Class Toxic; Danger of cumulative effects; Dangerous for the Environment
EC Risk Phrase R 23/24/25 33 52/53
EC Safety Phrase S 28 36/37 45 61
RTECS BY7000000
RTECS class Tumorigen; Mutagen; Reproductive Effector
UN (DOT) 1661
Merck 12,6681
Beilstein/Gmelin 508690
Beilstein Reference 4-12-00-01613
RCRA P077
Canada DSL/NDSL DSL
US TSCA Listed
Austrailia AICS Listed
New Zealand Listed
Japan ENCS (MITI) Listed
Korea ECL Listed

Properties.
Formula C6H6N2O2
Formula mass 138.12
Melting point, °C 148
Boiling point, °C 332
Vapor pressure, mmHg 0.0001 (25 C)
Vapor density (air=1) 4.77
Saturation Concentration 1.97 ppm (0.0001 %) at 20 C (calculated)
Density 1.24 g/cm3
Solubility in water 0.8 g/L
Viscosity 0.144 cp (172 C)
Surface tension 46.7 g/s2 (151 C)
Refractive index 1.5401 (160 C)
pKa/pKb 12.99 (pKb)
Partition coefficient, pKow 1.39
Heat of fusion 21.1 kJ/mol
Heat of vaporization 57.6 kJ/mol
Heat of combustion -3173 kJ/mol

Hazards and Protection.
Storage Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale.
Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Provide ventilation.
Disposal code 9
Stability Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities Strong acids, strong oxidizing agents, strong redcing agents.
Decomposition Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Fire.
Flash Point,°C 165
Autoignition, °C 500
Upper exp. limit, % 9.8
Lower exp. limit, % 1.5
Fire fighting Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.
Fire potential Slightly flammable. Will burn in air, producing highly toxic vapors.
Hazards When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products Toxic oxides of nitrogen may form in fire.
NFPA Health 3
  Flammability 1  
  Reactivity 2  

Health.
Exposure limit(s) OSHA PEL: TWA 6 mg/m3 (1 ppm) skin NIOSH REL: TWA 3 mg/m3 skin NIOSH IDLH: 300 mg/m3
Exposure effects Prolonged or repeated exposure may cause adverse reproductive effects. May cause liver and kidney damage. May cause bone marrow abnormalities with damage to blood forming tissues. May cause anemia and other blood cell abnormalities. Repeated exposure may cause central nervous system damage. Reproductive effects have been reported in animals.
   Ingestion May cause methemoglobinemia, cyanosis, convulsions, and death. Effects may be delayed 2 to 4 hours. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed. Alcohol can intensify effects.
   Inhalation May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia.
   Skin May cause skin irritation. Substance is rapidly absorbed through the skin. If absorbed, may cause symptoms similar to those for ingestion.
   Eyes May cause eye irritation. Vapors may cause eye irritation. May cause eye injury.

First aid		  
   Ingestion If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Induce vomiting by giving one teaspoon of Syrup of Ipecac.
   Inhalation Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number 1661
Response guide 153
Hazard class 6.1
Packing Group II  
USCG CHRIS Code NAL  
HS Code 2921 42 10