Acetylsalicylic acid

  • Aspirin
  • 2-(Acetyloxy)benzoic acid
  • o-Acetylsalicylic acid
Formula C9H8O4
Structure
Description Odorless white crystals or crystalline powder with a slightly bitter taste.
Uses Medication.

Registry Numbers and Inventories.
CAS 50-78-2
EC (EINECS/ELINCS) 200-064-1
EC Risk Phrase R 22 36/37
EC Safety Phrase S 26 36/37/39
RTECS VO0700000
RTECS class Drug; Mutagen; Reproductive Effector; Human Data
UN (DOT) 2811
Merck 13,856
Beilstein/Gmelin 779271
Beilstein Reference 4-10-00-00138
EPA OPP 129061
Swiss Giftliste 1 G-3736
Canada DSL/NDSL DSL
US TSCA Listed
Austrailia AICS Listed
New Zealand Listed
Japan ENCS (MITI) Listed
Korea ECL Listed

Properties.
Formula C9H8O4
Formula mass 180.16
Boiling point, °C 140
Vapor pressure, mmHg 3E-5
Density 1.39 g/cm3
Solubility in water 3.3 g/L
Refractive index 1.5623 (20 C)
pKa/pKb 3.49 (pKa)
Partition coefficient, pKow 1.19
Heat of fusion 19.3 kJ/mol
Heat of vaporization 106.40 kJ/mol
Heat of combustion -3927 kJ/mol

Hazards and Protection.
Storage Store in a cool, dry place. Store in a tightly closed container.
Handling Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions.
Stability Stable under normal shipping and handling conditions.
Incompatibilities Strong alkali, hydrolyzes in moist air, decomposes in hot water.
Decomposition Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C 250
Fire fighting Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.
Fire potential This chemical is combustible.
Hazards Contact with metals may evolve flammable hydrogen gas.
Combustion products Fire may produce irritating, corrosive and/or toxic gases.
NFPA Health 2
  Flammability 1  
  Reactivity 0  

Health.
Exposure limit(s) OEL-UNITED KINGDOM:TWA 5 mg/m3
Poison_Class 3
Exposure effects Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes.
   Ingestion May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhibits platelet aggregation affecting bleeding
   Inhalation May cause respiratory tract irritation. Can produce anaphylactic shock with even small doses.
   Skin May cause skin irritation. Low hazard for usual industrial handling. Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes.
   Eyes May cause eye irritation and possible burns.

First aid		  
   Ingestion If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid.
   Inhalation Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number 2811
Response guide 154
Hazard class 6.1
Packing Group I; II; III  
USCG Compatatibility Group 4. Organic acids