Halothane
- 2-Bromo-2-chloro-1,1,1-trifluoroethane
- 1-Bromo-1-chloro-2,2,2-trifluoroethane
- 1,1,1-Trifluoro-2-Bromo-2-chloroethane
- 2,2,2-Trifluoro-1-Bromo-1-chloroethane
Halothane | |
| |
| Formula | CF3CHClBr |
| Structure | |
| Description | Clear colorless highly volatile liquid with a sweet chloroform-like odor. |
| Uses | Medication (vet). |
| Registry Numbers and Inventories. | |
| CAS | 151-67-7 |
| EC (EINECS/ELINCS) | 205-796-5 |
| EC Risk Phrase | R 36 40 |
| EC Safety Phrase | S 26 36/37/39 |
| RTECS | KH6550000 |
| RTECS class | Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant |
| UN (DOT) | 1610 |
| Merck | 13,4619 |
| Beilstein/Gmelin | 1736947 |
| Beilstein Reference | 4-01-00-00156 |
| Austrailia AICS | Listed |
| New Zealand | Listed |
| Japan ENCS (MITI) | Listed |
| Korea ECL | Listed |
| Properties. | |
| Formula | C2HBrClF3 |
| Formula mass | 197.38 |
| Boiling point, °C | 50.2 |
| Vapor pressure, mmHg | 753 (50 C) |
| Vapor density (air=1) | 6.9 |
| Density | 1.86 g/cm3 |
| Solubility in water | 3 g/L |
| Refractive index | 1.3696 (20 C) |
| Partition coefficient, pKow | 2.30 |
| Heat of vaporization | 29.56 kJ/mol |
| Heat of combustion | -762 kJ/mol |
| Hazards and Protection. | |
| Storage | Store below 40C (104F), preferably between 15 and 30C (59 and 86F), unless otherwise specified by manufacturer. Store in a tight, light resistant container. |
| Handling | All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. |
| Protection | Wear appropriate protective gloves, clothing and goggles. |
| Respirators | Wear positive pressure self-contained breathing apparatus (SCBA). |
| Small spills/leaks | If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Stability | Sensitive to light, may be stabilized with 0.01% Thymol. |
| Incompatibilities | Sensitive to exposure to light Incompatible with oxidizing materials It |
| Fire. | ||||
| Fire fighting | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. | |||
| Fire potential | This material is nonflammable | |||
| Hazards | Containers may explode when heated. | |||
| Combustion products | All fluorocarbons will undergo thermal decomposition when exposed to flame or red-hot metal.Decomposition products of the chlorofluorocarbons will include hydrofluoric and hydrochloric acid along with smaller amounts of phosgene and carbonyl fluoride. | |||
| Health. | |
| Exposure limit(s) | TLV: 50 ppm; 404 mg/m3 (ACGIH 1992-1993). PDK: 20 mg/m3 C (USSR 1993). NIOSH REL: C 2 ppm (16.2 mg/m3) 60-minute *Note: REL for exposure to waste anesthetic gas. |
| Exposure effects | Primary toxic effects include abnormally low blood pressure, low heart rate, and respiratory depression. With therapeutic use - 1. Malignant elevated body temperature is a rare complication of halothane anesthesia. Coma may occur after ingestion or injection. |
| Ingestion | Vomiting may occur after halothane ingestion. |
| Inhalation | Inhalation of vapors or dust is extremely irritating. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. |
| Skin | An acneiform eruption due to hypersensitivity was reported in one patient occupationally exposed to halothane. |
| Eyes | Mydriasis was reported in one comatose patient after ingestion of 250 mL. Prolonged dialation of the pupils was not thought to be due to anoxia. Halothane has been reported to lower intraocular pressure. |
First aid |
|
| Ingestion | DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. |
| Inhalation | IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used. |
| Skin | IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. |
| Eyes | First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Transport. | ||
| UN number | 1610 | |
| Response guide | 159 | |
| Hazard class | 6.1 | |