Isopropyl acetate

  • Acetic acid, isopropyl ester
  • sec-Propyl acetate
  • 1-Methylethyl acetate
  • 2-Propyl acetate
  • 2-Acetoxypropane
Formula CH3COOCH(CH3)2
Structure
Description Clear, colorless liquid with an acetic odor.
Uses Solvent for cellulose derivatives, plastics, oils, and fats, in perfumery.

Registry Numbers and Inventories.
CAS 108-21-4
EC (EINECS/ELINCS) 203-561-1
EC Index Number 607-024-00-6
EC Class Highly flammable; Irritant; Repeated exposure may cause skin dryness or cracking; Vapours may cause drowsiness and dizziness
EC Risk Phrase R 11 36 66 67
EC Safety Phrase S 16 26 29 33
RTECS AI4930000
RTECS class Human Data; Primary Irritant
UN (DOT) 1220
Merck 13,5225
Beilstein/Gmelin 1740761
Beilstein Reference 4-02-00-00141
EPA OPP 508100
Swiss Giftliste 1 G-1711
Canada DSL/NDSL DSL
US TSCA Listed
Austrailia AICS Listed
New Zealand Listed
Japan ENCS (MITI) Listed
Korea ECL Listed

Odor Threshold Odor threshold 0.19 mg/m3
Properties.
Formula C5H10O2
Formula mass 102.13
Melting point, °C -62
Boiling point, °C 85
Vapor pressure, mmHg 61 (25 C)
Vapor density (air=1) 3.5
Saturation Concentration 6.25% (20 C)
Evaporization number 3.0 (butyl acetate=1)
Critical temperature 257
Critical pressure 32.4
Density 0.8732 g/cm3
Solubility in water 30 g/L (20 C)
Viscosity 0.0049 g/(cm s) (25 C)
Surface tension 22.1 g/s2 (21 C)
Refractive index 1.4862 (20 C)
Dipole moment 1.87 (25 C)
Partition coefficient, pKow 1.06
Heat of vaporization 32.9 kJ/mol
Heat of combustion -2064 kJ/mol

Hazards and Protection.
Storage Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
WHMIS B2
Handling Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Disposal code 1
Stability Stable under normal temperatures and pressures.
Incompatibilities Oxidizing agents, strong acids, nitrates, plastics, rubber, alkalies.
Decomposition Carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C 2
Autoignition, °C 479
Upper exp. limit, % 87.2
Lower exp. limit, % 1.8
Fire fighting Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical or carbon dioxide.
Fire potential Flammable liquid and vapor.
Hazards Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. May polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Combustion products Fire may produce irritating, corrosive and/or toxic gases.
NFPA Health 1
  Flammability 3  
  Reactivity 0  

Health.
Exposure limit(s) TLV: 250 ppm; 1040 mg/m3 (as TWA) (ACGIH 1997). TLV (as STEL): 310 ppm; 1290 mg/m3 (ACGIH 1997). OSHA PEL: TWA 250 ppm (950 mg/m3) NIOSH REL: See Appendix D NIOSH IDLH: 1800 ppm
Poison_Class 5
Exposure effects Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. Prolonged or repeated skin contact may cause defatting and dermatitis. Chronic exposure may cause liver damage.
   Ingestion May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
   Inhalation Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Inhalation of vapor may cause respiratory tract irritation. May cause effects similar to those described for ingestion. May cause narcotic effects in high concentration. Causes irritation of mucous membrane.
   Skin Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. May cause skin burns. Chronic exposure may cause liver damage.
   Eyes Causes eye irritation.

First aid
 
   Ingestion Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number 1220
Response guide 129
Hazard class 3
Packing Group II  
USCG CHRIS Code IAC  
USCG Compatatibility Group 34 Esters
HS Code 2915 39 10  
Std. Transport # 4909210  
IMO Chemical Code 18
IMO Pollution Category III