Nicotine

  • 3-(1-methyl-2-pyrrolidinyl)pyridine
  • (S)-3-(1-Methylpyrrolidin-2-yl)pyridine
  • 1-Methyl-2-(3-pyridyl)pyrrolidine
  • beta-Pyridyl-alpha-n-methylpyrrolidine
Formula C10H14N2
Structure
Description Colorless to pale yellow, oily liquid, turns brown on exposure to air and light. Develops fish-like odor when warm. Hygrosopic.
Uses Insecticide (former use), fumigant (former use).

Registry Numbers and Inventories.
CAS 54-11-5
EC (EINECS/ELINCS) 200-193-3
EC Index Number 614-001-00-4
EC Class Very toxic; Toxic; Dangerous for the Environment
EC Risk Phrase R 25 27 51/53
EC Safety Phrase S 36/37 45 61
RTECS QS5250000
RTECS class Agricultural Chemical and Pesticide; Mutagen; Reproductive Effector; Human Data; Natural Product
UN (DOT) 1654
Merck 12,6611
Beilstein/Gmelin 82109
Beilstein Reference 5-23-06-00064
RCRA P075
EPA OPP 56702
Swiss Giftliste 1 G-2057
Canada DSL/NDSL DSL
US TSCA Listed
Austrailia AICS Listed
New Zealand Listed
Japan ENCS (MITI) Listed
Korea ECL Listed

Properties.
Formula C10H14N2
Formula mass 162.24
Melting point, °C -79
Boiling point, °C 247
Vapor pressure, mmHg 0.03 (25 C)
Vapor density (air=1) 5.61
Saturation Concentration 56 ppm (0.0056%) at 20 C (calculated)
Density 1.01 g/cm3 (25 C)
Solubility in water Soluble
Surface tension 38.61 g/s2
Refractive index 1.5282 (20 C)
pKa/pKb 6.00 (pKb)
Partition coefficient, pKow 1.17
Heat of vaporization 48.1 kJ/mol
Heat of combustion -5910 kJ/mol

Hazards and Protection.
Storage Keep away from sources of ignition. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from strong acids.
Handling Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not reuse this container. Do not get on skin or in eyes. Do not ingest or inhale.
Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear impervious gloves. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks Avoid runoff into storm sewers and ditches which lead to waterways. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite.
Disposal code 9
Stability Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities Strong acids, strong oxidizers.
Decomposition Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C 101
Autoignition, °C 240
Upper exp. limit, % 4
Lower exp. limit, % 0.7
Fire fighting Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Can form explosive mixtures at temperatures above the flashpoint. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water or foam may cause frothing.
Fire potential Slightly flammable. Flammable if preheated.
Hazards There is a moderate explosion hazard when exposed to heat or flame. When heated to decomposition, it emits nitrogen oxides, carbon monoxide and other highly toxic fumes. Avoid oxidizing materials. Stable under normal conditions. Avoid heat or flames.
Combustion products When heated, emits highly toxic fumes.
NFPA Health 3
  Flammability 1  
  Reactivity 0  

Health.
Exposure limit(s) TLV: 0.5 mg/m3 (as TWA) (skin) (ACGIH 1996). MAK: 0.07 ppm; 0.5 mg/m3; H (1996). OSHA PEL: TWA 0.5 mg/m3 skin NIOSH REL: TWA 0.5 mg/m3 skin NIOSH IDLH: 5 mg/m3
Poison_Class 1
Exposure effects May cause digestive tract and cardiac disturbances.
   Ingestion May be fatal if swallowed. May cause adverse effects of the musculature. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause tremors and convulsions. May cause muscle paralysis, respiratory failure, and possible death. Exposure causes initial nervous system stimulation followed by severe CNS depression. May cause ataxia and
   Inhalation May cause effects similar to those described for ingestion.
   Skin May cause skin irritation. May be fatal if absorbed through the skin.
   Eyes May cause eye irritation.

First aid
 
   Ingestion If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
   Eyes Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number 1654
Response guide 151
Hazard class 6.1
Packing Group II  
USCG CHRIS Code NIC  
HS Code 2939 99 90  
Std. Transport # 4921785 4925274