Phenothiazine
- Thiodiphenylamine
- Dibenzothiazine
Phenothiazine | |
| |
| Formula | C12H9NS |
| Structure | |
| Description | Greyish-green to greenish-yellow solid, slight odor. |
| Uses | Manufacture of dyes, parent compound for chlorpromazine & related antipsychotic drugs, polymerization inhibitor, antioxidant. |
| Registry Numbers and Inventories. | |
| CAS | 92-84-2 |
| EC (EINECS/ELINCS) | 202-196-5 |
| EC Risk Phrase | R 52/53 |
| EC Safety Phrase | S 60 |
| RTECS | SN5075000 |
| RTECS class | Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Human Data |
| UN (DOT) | 3077 |
| Merck | 12,7404 |
| Beilstein/Gmelin | 143237 |
| Beilstein Reference | 4-27-00-01214 |
| EPA OPP | 64501 |
| Swiss Giftliste 1 | G-2714 |
| Canada DSL/NDSL | DSL |
| US TSCA | Listed |
| Austrailia AICS | Listed |
| New Zealand | Listed |
| Japan ENCS (MITI) | Listed |
| Korea ECL | Listed |
| Properties. | |
| Formula | C12H9NS |
| Formula mass | 199.28 |
| Melting point, °C | 182 - 185 |
| Boiling point, °C | 371 |
| Vapor pressure, mmHg | 1E-5 (25 C) |
| Saturation Concentration | Nearly zero |
| Density | 1.34 g/cm3 (20 C) |
| Solubility in water | Insoluble |
| Refractive index | 1.6353 (212 C) |
| pKa/pKb | 11.48 (pKb) |
| Partition coefficient, pKow | 4.15 |
| Heat of vaporization | 61.8 kJ/mol |
| Hazards and Protection. | |
| Storage | Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. |
| Handling | Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. |
| Protection | Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. |
| Respirators | Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. |
| Small spills/leaks | Vacuum or sweep up material and place into a suitable disposal container. |
| Disposal code | 3 |
| Stability | Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air. |
| Incompatibilities | Strong oxidizing agents - strong acids. |
| Decomposition | Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. |
| Fire. | ||||
| Flash Point,°C | 202 | |||
| Autoignition, °C | 470 | |||
| Fire fighting | Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Flammable solid. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam. | |||
| Fire potential | Although phenothiazine oxidizes fairly easily when it is exposed to air, risk of fire is not high. | |||
| Combustion products | if involved in fire, phenothiazine produces highly toxic sulfur and nitrogen oxides, which are dangerous lung irritants. | |||
| NFPA | Health | 2 | ||
| Flammability | 2 | |||
| Reactivity | 0 | |||
| Health. | |
| Exposure limit(s) | TLV: ppm; 5 mg/m3 (as TWA) (skin) (ACGIH 1996). NIOSH REL: TWA 5 mg/m3 skin |
| Poison_Class | 3 |
| Exposure effects | Chronic inhalation may cause effects similar to those of acute inhalation. |
| Ingestion | May cause irritation of the digestive tract. |
| Inhalation | Causes respiratory tract irritation. May cause liver and kidney damage. May cause anemia. |
| Skin | Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Substance is rapidly absorbed through the skin. May cause dermatitis. Contact with the skin may cause photosensitivity. |
| Eyes | Causes eye irritation. May cause painful sensitization to light. Causes redness and pain. |
First aid |
|
| Ingestion | If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. |
| Inhalation | Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. |
| Skin | Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. |
| Eyes | Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. |
| Transport. | ||
| UN number | 3077 | |
| Response guide | 171 | |
| HS Code | 2934 30 90 | |