Picloram
- 4-Amino-3,5,6-trichloro-2-pyridinecarboxylic acid
- 4-Amino-3,5,6-trichloropicolinic acid
- 4-Amino-3,5,6-Trichloropyridine-2-carboxylic acid
Picloram | |
| |
| Formula | C6H3Cl3N2O2 |
| Structure | |
| Description | Fine beige crystals or white powder. Odor of chlorine. |
| Uses | Systemic herbicide. |
| Registry Numbers and Inventories. | |
| CAS | 1918-02-1 |
| EC (EINECS/ELINCS) | 217-636-1 |
| RTECS | TJ7525000 |
| RTECS class | Agricultural Chemical and Pesticide; Tumorigen; Mutagen; Reproductive Effector |
| Merck | 12,7552 |
| Beilstein/Gmelin | 479075 |
| Beilstein Reference | 5-22-13-00585 |
| EPA OPP | 5101 |
| Swiss Giftliste 1 | G-3306 |
| Canada DSL/NDSL | NDSL |
| US TSCA | Listed |
| Austrailia AICS | Listed |
| New Zealand | Listed |
| Properties. | |
| Formula | C6H3Cl3N2O2 |
| Formula mass | 241.46 |
| Melting point, °C | 218 - 219 |
| Boiling point, °C | 366 |
| Vapor pressure, mmHg | 0.000000616 |
| Solubility in water | 400 mg/L |
| pKa/pKb | 3.6 (pKa) |
| Partition coefficient, pKow | 1.89 |
| Hazards and Protection. | |
| Storage | Keep containers closed. |
| Handling | All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. |
| Protection | Wear appropriate eye protection and protective clothing to prevent skin and eye contact. |
| Respirators | Use NIOSH/MSHA approved respirator appropriate for exposure of concern. |
| Small spills/leaks | If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Stability | Low volatility storage Stability: A minimum of 2 years the expected shelf life of concentrated chemical is approximately three years in aqueous solution, decomposed by UV irradiation. |
| Incompatibilities | May be sensitive to prolonged exposure to light Incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. |
| Fire. | ||||
| Fire fighting | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. | |||
| Fire potential | This material is probably combustible. | |||
| Health. | |
| Exposure limit(s) | TLV: ppm; 10 mg/m3 (as TWA) (ACGIH 1993-1994). OSHA PEL: TWA 15 mg/m3 (total) TWA 5 mg/m3 (resp) NIOSH REL: See Appendix D |
| Poison_Class | 4 |
| Exposure effects | Although seizures have not been reported in humans, seizures have developed in animals exposed to fatal amounts. No teratogenicity was observed in several studies. However, there are reports that Tordon 202c (a picloram and 2,4-D combination herbicide) showed teratogenesis and fetal growth depression in mice by paternal exposure and combined preconceptional and gestational exposure. |
| Ingestion | Nausea is possible after ingestion of massive amounts of picloram. |
| Inhalation | Picloram dust is irritating to the respiratory tract. |
| Skin | Picloram is mildly irritating to skin. |
| Eyes | Eye irritation may occur with exposure to picloram. |
First aid |
|
| Ingestion | DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. |
| Inhalation | IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used. |
| Skin | IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. |
| Eyes | First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Transport. |